DiaB12, opinions and questions

Good morning, after a withdrawal break I change the contraceptive pill from Jeanine to Belara. So far I have taken pills at 15 o'clock, will starting taking pills at 12 o'clock after a withdrawal break negatively affect the effectiveness of contraception? I still have a question about metformax - I start taking Metformax 500 (1 tablet a day) during the break from discontinuation, can it negatively affect the effectiveness of contraception? Should I take probiotics while taking metformax?