Will the interval of 6 months between two doses of smallpox still give almost 99% protection against getting sick?
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Angelika Talar-Śpionek Pharmacist, Editor
18 months ago
The second dose of Varilrix should be given at least 6 weeks after the first dose. If the doses were taken at approximately half-year intervals - the effect of the drug will be ensured, the vaccine has been administered correctly. "In vaccinated children aged 9 months to 6 years, seroconversion (antibodies measured by IFA) 6 weeks after the second dose was found in 100% of the vaccinated. After the second dose, a significant increase in antibody titre was observed (5-26 times increase in geometric mean antibody titer). In vaccinated subjects aged 13 years and older, seroconversion (antibodies measured by IFA) was observed 6 weeks after the second dose in 100% of vaccinated patients. One year after vaccination, all subjects tested positive for antibodies." Although efficacy has not been studied at 6-month intervals, a significant increase in antibody titres can be expected after the 2nd dose. However, we are not able to determine whether the effectiveness will be 99%. I enclose a link to pages where you can find more information about the vaccine: https://www.gdziepolek.pl/produkty/81391/varilrix-iniekcja/apteki