Is spotting when using Estrofem before embryo transfer correct?

Estrofem is a preparation of estrogen, a hormone conditioning, among others, the growth of the uterine mucosa and I am one of the drugs that is sometimes used for embryo transfer in a cycle with estrogen-progesterone therapy (the so-called cycle during hormone therapy). According to the information of the manufacturer of the drug and the specifics of the action of estrogen, women with a preserved uterus during the first months of treatment may experience bleeding or spotting. However, the whole record refers to hormone replacement therapy rather than embryo transfer. Perhaps there is no reason for concern, but this question is best answered by your doctor and all such doubts are worth consulting with him. Estrogens can affect the replacement of thyroid hormone levels.