Does Depo-Medrol cause weight gain?

I think the question is unfinished, but let me answer the first part. Each vial of Depo - Medrol contains 40 mg of methylprednisolone acetate, m.in used for short-term use in rheumatic diseases. In your case, the drug was administered topically, probably intraarticularly. Corticosteroids, including methylprednisolone, can increase blood glucose levels, worsen existing diabetes, and increase the risk of diabetes in people chronically taking corticosteroids. Methylprednisolone among its side effects causes increased appetite and therefore weight gain, the frequency of this side effect is defined as unknown, but it is much more likely to be expected when the drug is administered regularly at short intervals. More information about the drug can be found at the link: https://www.gdziepolek.pl/produkty/21946/depo-medrol-iniekcja