Can side effects occur after prolonged use of pregabalin and duloxetine?

After a long, over 1.5 year of pregabalin use (from January 2x150) and four months of Dutilox (60+30), can symptoms of loss of consciousness occur suddenly, on average once a week? Could there have been an oversaturation? I do not take other drugs, sometimes a supplement of some kind. The diagnosis does not show any other possible causes (the only hypotheses are the connection with the blocks of the branches of the Hissa bundle {for several years} or the possible hidden passage of Covid) -