I take polprazole 20, beto 25 and debu-activ, should I keep any intervals between medications?

According to the current medical literature, there should be no interactions between the preparations mentioned by you that are harmful to health or the effects of medicines. Polprazole is usually taken in the morning on an empty stomach, half an hour before breakfast. Beto ZK is best taken during breakfast. Debu activ is best taken during the aftermath,twice a day - in the morning and in the evening. Acard is best taken in the evening, after a meal. Most of the painkillers belonging to the NSAID group interact with Acard. The therapeutic effect of NPLZ is weakened, while the side effect on the gastric mucosa is intensified. NPLZ drugs weaken the cardioprotective and anticoagulant effect of Acard. Studies have found an increase in the incidence of cardiovascular events. Therefore, it is recommended to take NPLZ drugs at least 30 minutes after (or more than 8 hours before) taking Acard. I also encourage you to read the article: https://www.gdziepolek.pl/artykuly/jakie-leki-przeciwbolowe-stosowac