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Przemysław L. (Anonymous, 89.64.124.) Warszawa 2 years ago

Can pantoprazole affect THC metabolism?

The question concerns the interaction of vaporized medical marijuana with proton pump inhibitors (with pantoprazole). Can such an interaction increase THC levels and slow down marijuana metabolism (its removal from the body)? There is no specific information on this subject, both at the doctor and on the Internet. Could a specialist comment on this topic? Thank you

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mikk (Anonymous, 188.212.135.) 2 years ago

Here is a nice foreign site for checking interactions between drugs (cannabis -> cannabis): google "drug interaction checker" - the site has drugs_com in its name Unfortunately there are restrictions on testing several substances at the same time (3 at once from what I remember went through).

Angelika Talar-Śpionek Pharmacist, Editor

2 years ago

In the available sources, I do not find information that dried medical marijuana - including the THC contained in it interacts with proton pump inhibitors. Given the mechanism of action of pantoprazole drugs, they are unlikely to slow down the metabolism of THC, a cannabinoid delivered to the body in an inhaled form. However, there are a number of studies confirming the effectiveness of THC in the treatment of stomach ulcer. Scientists have proven that it can be an effective drug that is an alternative to other agents - that is, when, for example, pantoprazole or other drugs are ineffective. "A study conducted at the University of West Virginia and published in the European Journal of Pharmacology in 2013 looked at the effects of cannabis on peptic ulcer disease caused by taking diclofenac (a very commonly used non-steroidal analgesic and anti-inflammatory drug) in mice. Thc has been shown to have a strong protective effect on the gastric and duodenal mucosa, reducing the risk of peptic ulcer disease and its severe complications such as gastrointestinal bleeding. What's more, the protective doses were so low that they did not cause THC-specific psychoactive effects – mice in intelligence tests achieved identical results as those not tested. Researchers postulate activation of the cb1 endocannabinoid receptor as a mechanism of medicinal action of cannabis in gastric and duodenal ulcers." "Other scientific publications also confirm the beneficial effects of medical marijuana in peptic ulcer disease or gastritis, consisting in reducing the secretion of hydrochloric acid. What's more, not only THC but also other cannabinoids such as cannabidiol – CBD or cannabinol – CBN have protective properties for the mucous membrane of the gastrointestinal tract: they reduce inflammation, have antiemetic and analgesic properties, significantly improving the patient's comfort. Unlike other drugs used in the treatment of peptic ulcer disease, medical marijuana is the only one that acts simultaneously diastolic and normalizes bowel function, often disturbed by stomach or duodenal ulcers – patients often complain of colic intestinal pain, diarrhea and constipation. As you can see, cannabis works more broadly, more effectively improving the patient's quality of life."

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