Naltrexone works in opioid addiction by blocking the appropriate opioid receptors in the brain, thus canceling out the effects of opioids (which include tramadol contained in Doreta) and supporting recovery from addiction. The patient no longer feels euphoric, which limits the desire to reach for the drug. Taking it concomitantly with opioids, especially high doses of opioids, can indeed lead to the appearance of withdrawal symptoms (including respiratory and circulatory system disorders), which can be life-threatening due to the increased risk of opioid overdose. These symptoms can appear within 5 minutes of taking the drug and last up to 48 hours, and their treatment is symptomatic. Therefore, it is recommended to use naltrexone after (gradual) withdrawal from opioids, under close medical supervision, and pain should only be managed with non-opioid analgesics during its use.

The doctor, based on his knowledge, clinical experience and the patient's health condition, can always recommend a procedure other than that contained in the Package Leaflet or the Summary of Product Characteristics. If you have any doubts about the recommended treatment, I encourage you to consult your doctor and present your concerns to him. If necessary, the Gdziepolek.pl portal allows you to use teleconsultations:

https://www.gdziepolek.pl/telekonsultacja

I encourage you to read:

https://www.gdziepolek.pl/artykuly/jakie-leki-powoduja-uzaleznienie

https://youtu.be/FhKTxYyXqNY?si=LuHQNYfdswiu4ZZf