Does prolonged use of primolut in childbearing age promote or protect against osteoporosis? Thank you
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Anna Lewandowska Pharmacist, Editor
58 days ago
Long-term use of Primolut Nor (Norethisterone) during childbearing age does not protect against osteoporosis, but may promote it due to the drug-induced estrogen deficiency. To prevent osteoporosis in these circumstances, estrogen replacement hormone therapy may be necessary.
Norethisterone is a synthetic progestin that, when taken alone, can cause a decrease in endogenous estrogen levels as a result of inhibition of ovulation. Estrogens play a key role in maintaining bone health in women of childbearing age by promoting calcium absorption and reducing bone resorption.
Therefore, long-term use of Primolut-Nor in the absence of an adequate dose of estrogen can lead to a decrease in bone mineral density and increase the risk of osteoporosis. This negative effect on bone metabolism is particularly relevant if treatment lasts several months or years.
If you have doubts about this situation, it is always worth consulting a doctor who can provide more personalized advice. If you are not able to make a face-to-face visit, I attach a link to the online teleconsultation: