In what mechanism and for how long can Ketoprofen reduce the effectiveness of the Kyleena intrauterine device?

Please:

1. Effect of oral ketoprofen on pain perception during copper IUD insertion among parous women: A randomized double-blind controlled trial; Middle East Fertility Society Journal 23(4) February 2018

A randomized, double-blind controlled trial found no effect of oral ketoprofen on copper IUD performance in women:

https://www.researchgate.net/publication/322890469_Effect_of_oral_ketoprofen_on_pain_perception_during_copper_IUD_insertion_among_parous_women_A_randomized_double-blind_controlled_trial

2. Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use; Cochrane Database Syst Rev. 2022; August 2022 (8)

Literature review on the prevention or treatment of heavy menstrual bleeding and pain associated with the use of an IUD

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413853/

3. Analgesics for intrauterine device placement; Cochrane Database Syst Rev. 2022; 2022(10), October 2022

Literature review on the effectiveness of painkillers during intrauterine device (IUD) insertion

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560477/

Can you please cite these studies?

Do@Ala929: The answer you quoted is from 2 years ago. Current research indicates that ketoprofen does not affect the effectiveness of the IUD.

Under another question, the editor wrote that ketoprofen may reduce the effectiveness of IUDs - https://www.gdziepolek.pl/opinie-i-pytania/45921/jakie-leki-przeciwbolowe-i-rozkurczowe-mozna-stosowac-podczas-noszenia-wkladki-domacicznej. I just don't know how long and why this is happening.